Duke's OSA/SPIE Chapter
Siavash Yazdanfar, Ph.D.
GE Global Research
When: Tuesday, September 12,
2006, 12:00-1:00 PM
Where: FCIEMAS Schiciano
Pizza and round table discussion with the
speaker following the talk! Meet a young professional and talk to him about
the distinction between industry and academics.
Near-Infrared Fluorescence Imaging"
I will describe a low-cost, safe, and easy to use near
infrared (NIR) fluorescence intraoperative imaging system that permits the
surgeon to see, in real time, surgical anatomy and NIR fluorescence
simultaneously. Surgical resection of tumors remains the primary method of
treatment for cancer in the early stages. Complete removal of the tumor
prior to metastasis, which generally occurs through the lymphatic system, is
the best way to ensure a full recovery and minimize the risk of recurrence.
The presence of cancer cells in regional lymph nodes is an indicator of
metastasis and necessitates more aggressive systemic treatment such as
chemotherapy. Identifying and removing the first lymph node to receive
lymphatic drainage, i.e., the sentinel lymph node (SLN), minimizes the
number of biopsies required to stage cancer. Furthermore, tumor margins are
poorly defined and difficult to visualize, resulting in relatively high
recurrence rates in many forms of cancer. Providing an intraoperative visual
aid to the surgeon, during tumor resection as well as SLN mapping, can
potentially help ensure the complete removal of diseased tissue.
This work is partially funded by the National Institutes
of Health (NIH).
Siavash joined the Applied Optics Laboratory at GE Global
Research in 2005. He is currently a project leader in Optical Imaging. Prior
to GE, Siavash was a postdoctoral associate at the Massachusetts Institute
of Technology, advancing instrumentation for nonlinear optical microscopy
techniques such as two-photon fluorescence and second harmonic generation.
He received a MS and PhD in biomedical engineering from Case Western Reserve
University. His graduate research was on noninvasive blood flow imaging in
human retina and skin by use of optical coherence tomography. His research
interests are primarily in the area of biomedical optical imaging and
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